Brand Name: Glimet Forte Tablet
Active Ingredients: Glibenclamide 5 mg / Metformin HCL 800 mg
When is Glimet Forte Tablet prescribed for?
Glimet Forte is indicated in the treatment of type 2 diabetes mellitus where diet alone or diet and sulfonylurea cannot satisfactorily lower blood glucose levels.
How should you take Glimet Forte Tablet?
- Glimet Forte should be given with meal.
- The usual starting dose is 2 tablets per day at the main meal. In any event it is inadvisable to exceed 2 gm daily of metformin.
- The daily dose should then be gradually decreased until the minimum amount needed to control blood glucose levels is achieved.
- Over dosage can cause hypoglycaemia which in turn can lead to behaviour changes and coma.
- The patient should be given oral or intravenous glucose.
- There may also appear gastrointestinal symptoms and signs of hyperlactacidemia that require hospitalization and treatment of lactic acidosis.
When you should not take Glimet Forte Tablet?
- Hypersensitivity to Glibenclamide or Metformin HCl
- Latent diabetes, suspected diabetes, diabetes in pregnancy, insulin dependent diabetes, diabetic coma.
- Renal dysfunction and congestive heart failure.
Special warning and precautions on using Glimet Forte Tablet:
- Glimet Forte should not be used during pregnancy and lactation.
- In the events of symptoms of hypoglycaemia (headache, irritability, sleep disorders, depression, tremors, sweating) give carbohydrates (sugar).
- The risk of lactic acidosis (anorexia, nausea ,fever, vomiting, increases respiratory frequency ,malaise, abdominal pain, diarrhoea ,blackout or loss of consciousness) is more frequent in:
- Patients over 60 years of age
- In Patients with impaired renal and/or liver function, cardio- respiratory insufficiency, alcoholism, prolonged fasting, undergoing treatment with diuretics and in case of gastrointestinal disorders.
So, that the physician should also be informed.
Possible Drug interaction with Glimet Forte Tablet
The glucose-lowering effect of sulfonyl-urea can be:
- Increased by Dicumarol and dicumarol derivatives, by mono aminoxidase inhibitor, by sulfa drug, phenylbutazone and its derivative, perhexiline and large amounts of alcohol.
- It is decreased by adrenalin, corticosteroids, contraceptives, thiazide diuretic and barbiturates.
- Caution must be exercised when administering along with beta-blockers.
- Biguanides may increase the effects of anticoagulants.
Possible Side effects with Glimet Forte Tablet
- Hypoglycemia may occur rarely especially in elderly patient.
- Gastro-intestinal reaction such as nausea, gastralgia, vomiting, diarrhoea, anorexia