Brand Name: Sycocetam Oral Solution
Active Ingredient: Levetiracetam
When is Sycocetam Oral Solution prescribed for?
- Sycocetam is indicated as monotherapy in the treatment of partial onset seizures with or without secondary generalisation in patients from 16 years of age with newly diagnosed epilepsy.
- Sycocetam is indicated as adjunctive therapy:
- In the treatment of partial onset seizures with or without secondary generalisation in adults and children from 1 month of age with epilepsy.
- In the treatment of myoclonic seizures in adults and adolescents from 12 years of age with Juvenile Myoclonic Epilepsy.
- In the treatment of primary generalised tonic-clonic seizures in adults and adolescents from 6 years of age with Idiopathic Generalised Epilepsy.
How should you take Sycocetam Oral Solution?
Simple titration for monotherapy in adults:
|
|
Starting dose and first two weeks |
Increase/decrease after two weeks |
Maximum recommended dose |
|
Oral solution(100mg/ml) |
2.5 ml b.d |
2.5 ml b.d |
15 ml b.d |
Simple dosing for adjunctive therapy in children and infants > or = 1 month old:
|
Therapeutic starting dose |
Increase/decrease 2-4 weeks |
Maximum recommended dose |
|
1 month to < 6 months: |
||
|
7 mg/kg b.d. |
7 mg/kg b.d. (14mg/kg b.d) |
21 mg/kg b.d. |
|
6 months to < 4 years: |
||
|
10 mg/kg b.d. |
10 mg/kg (20 mg/kg b.d.) |
25 mg/kg b.d |
|
4 years to < 16 years |
||
|
10 mg/kg b.d |
10 mg/kg (20mg/kg b.d.) |
30 mg/kg b.d. |
Simple dosing for adjunctive therapy in adults:
|
|
Therapeutic Starting dose |
Increase/decrease two-four weeks |
Maximum recommended dose |
|
Oral solution(100mg/ml) |
5 ml b.d |
5 ml b.d |
15 ml b.d |
When Sycocetam Oral Solution must not be prescribed?
Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients.
Possible drug interaction with Sycocetam Oral Solution:
Up till now no clinically significant drug-drug interacting.
Some Warnings and Precautions with Sycocetam Oral Solution:
• Renal insufficiency
The administration of Sycocetam to patients with renal impairment may require dose adjustment.
• Hepatic insufficiency
In patients with severely impaired hepatic function, assessment of renal function is recommended before dose selection
Possible Side Effects with Sycocetam Oral Solution::
- The most commonly reported adverse reactions were somnolence, asthenia and dizziness.
- In the pooled safety analysis, there was no clear dose-response relationship but incidence and severity of the central nervous system related adverse reactions decreased over time.